People with high or medium genetic risk for abdominal pain obesity But those with a healthy lifestyle are less likely to develop coronary heart disease (CHD) than those with low genetic risk and an unhealthy lifestyle, a study has shown.
A total of 282,316 White British individuals from the UK Biobank were assessed in this study. The authors estimated the genetic risk of high waist-to-hip ratio (WHR) via weight polygenic risk scores (PRS), calculated based on 156 single-nucleotide polymorphisms.
Lifestyle scores were calculated based on five healthy factors: regular physical activity, not currently smoking, healthy diet, <3 times/week of alcohol consumption, and 7 to 9 hours of sleep per day. day.
A total of 11,635 coronary events occurred during a median follow-up of 13.8 years. Twelve individual cardiovascular disease (CVD) risk markers were assessed at baseline.
Adherence to a healthy lifestyle (4 to 5 healthy factors) resulted in a 25% reduction (relative risk, 0.75, 95% confidence interval (CI), 0.70 to 0.81) in risk of coronary heart disease in relation to an unfavorable lifestyle (factor 0 to 1). ), independent of PRS for high WHR.
Participants with a favorable lifestyle at high or medium genetic risk had a lower estimated 12-year absolute risk of coronary heart disease than those with an unfavorable lifestyle at low genetic risk (1.73 percent and 1.67 percent compared to 2.08 percent).
Following a healthy lifestyle contributed to healthier levels of cardiovascular disease risk markers (except random glucose and high-density lipoprotein), independent of PRS for high WHR.
“Future clinical trials of lifestyle modification could be implemented in individuals at high genetic risk for abdominal obesity for primary prevention of coronary events,” the authors said.
